Home › Chemicals › Chloroform CAS 67-66-3: Chloroform (CHCl3) Identity CAS Number 67-66-3 Molecular Formula CHCl3 IUPAC Name trichloromethane Molecular Weight 119.38 g/mol SMILES ClC(Cl)ClSynonyms trichloromethane, TCM, R-20
2D Structure
Physical Properties Density 1.489 g/mL at 25°C Boiling Point 61.2°C Melting Point -63.5°C Flash Point None°C Vapor Pressure 21.2 kPa at 20°C Refractive Index nD = 1.446 Dielectric Constant ε = 4.8
Safety & GHS Classification GHS06 Health Hazard
H302: Harmful if swallowed H315: Causes skin irritation H331: Toxic if inhaled H336: May cause drowsiness or dizziness H351: Suspected of causing cancer H373: May cause damage to organs through prolonged or repeated exposure (liver, kidneys) Storage: Store in dark, well-ventilated area. Decomposes to phosgene upon UV light exposure — add ethanol stabilizer (0.5-1%). Suspected carcinogen — minimize exposure. Use in fume hood with gloves.
Material Compatibility Matrix Plastics Material Rating PTFE Excellent PVC Poor PE Poor PP Fair PEEK Excellent PVDF Good
Rubbers Material Rating Viton Excellent NBR Fair EPDM Good Silicone Good FKM Excellent
Metals Material Rating Stainless 316 Excellent Aluminum Good Copper Good Brass Good
Applications Laboratory solvent (NMR, extraction) Pharmaceutical manufacturing Refrigerant (historical) Anesthetic (historical — no longer used) Pesticide intermediate Dye manufacturing Rubber solvent External References: PubChem
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